㈼-1-4-2 AF

㈼−1-4-2

片頭痛にセロトニンの異常はどう関与するのか

1) Anthony M, Hinterberger H, Lance JW. Plasma serotonin in migraine 　 and stress. Arch Neurol. 1967 May;16(5):544-52.
文献 PubMed−ID	PMID: 5297855
文献タイトル (日本語)	片頭痛とストレスにおける血漿セロトニン．
目的	一次性頭痛の病態生理を現在の仮説で解説．
備考	MeSH Terms: • Cerebral Ventriculography • Diarrhea • Human • Injections, Intramuscular • Migraine/blood* • Migraine/chemically induced • Reserpine • Serotonin/blood* • Stress/blood* • Vomiting Substances: • Reserpine ・ Serotonin
作成者	濱田潤一，永田栄一郎

2) Curran DA, Hinterberger H, Lance JW. Total plasma serotonin, 5- 　 hydroxyindoleacetic acid and p-hydroxy-m-methoxymandelic acid 　 excretion in normal and migrainous subjects. ABrain. 1965 　 Dec;88(5):997-1010.
文献 PubMed−ID	PMID: 5325360
文献タイトル (日本語)	健常者と片頭痛患者における血漿中のセロトニン， 5-hydroxyindoleacetic acid と p-hydroxy-m-methoxymandelic acid の代謝．
備考	Publication Types: • Clinical Trial MeSH Terms: • Adult • Blood • Clinical Trials • Female • Human • Hydroxyindoleacetic Acid/metabolism* • In Vitro • Male • Methysergide/therapeutic use • Middle Aged • Migraine/metabolism* • Serotonin/metabolism* • Urine Substances: • Mandelic Acids • Methysergide • Serotonin • Hydroxyindoleacetic Acid
作成者	濱田潤一，永田栄一郎

4) Lance JW, Anthony M, Hinterberger H. Serotonin and migraine. 　 TransAm Neurol Assoc. 1967;92:128-31.
文献 PubMed−ID	PMID: 5634006
文献タイトル (日本語)	セロトニンと片頭痛．
備考	MeSH Terms: • Human • Hydroxyindoleacetic Acid/blood • Methysergide/pharmacology • Migraine/blood • Migraine/etiology • Migraine/metabolism* • Norepinephrine/blood • Serotonin/blood • Serotonin/metabolism* • Serotonin Antagonists • Vanilmandelic Acid/blood Substances: • Serotonin Antagonists • Methysergide • Reserpine • Serotonin • Norepinephrine • Hydroxyindoleacetic Acid • Vanilmandelic Acid
作成者	濱田潤一，永田栄一郎

6) Ferrari MD. Biochemistry of migraine . Pathol Biol ( Paris ). 1992 　 Apr;40(4):287-92.
論文抄録	The biochemistry of migraine is complex. Many contradictory or never replicated findings in often small patient groups have been published. The following observations in the platelet-free plasma and urine appear to have some solid basis and will be discussed: 1) systemic derangement of 5-HT metabolism, relevant to the peripheral vascular component of migraine pathophysiology, 2) changes in neuroexcitatory amino acids and magnesium, which may reflect a predisposition of the migraine patient, notably those having attacks with aura, to develop spreading depression, 3) alterations in methionine-enkephalin levels, which may be a useful marker to discriminate between tension headache and migraine, 4) hormonal fluctuations which seem important to set the threshold for an attack, 5) changes of vasoactive peptides in the cranio-vascular circulation, providing the first human evidence that the trigemino-vascular system indeed is relevant in migraine, and 6) catecholaminergic changes suggesting sympathetic overactivity. Finally distinct biochemical differences between patients with migraine without aura and patients with tension headache on one hand, and between patients with migraine with aura and patients with migraine without aura on the other hand will be emphasized. Findings in platelets will be discussed only if they are complementary and supportive to the plasma and urine data.
文献 PubMed−ID	PMID: 1379706
文献タイトル (日本語)	片頭痛の生化学．
研究施設	Department of Neurology, Leiden University Hospital , The Netherlands .
備考	Publication Types: • Review • Review, Tutorial MeSH Terms: • Aspartic Acid/blood • Catecholamines/blood • Catecholamines/urine • Enkephalin, Methionine/blood • Estrogens/metabolism • Female • Glutamates/blood • Human • Hydroxyindoleacetic Acid/blood • Hydroxyindoleacetic Acid/urine • Male • Migraine/blood* • Migraine/urine • Neuropeptides/blood • Serotonin/blood • Serotonin/urine • beta-Endorphin/blood Substances: • Catecholamines • Estrogens • Glutamates • Neuropeptides • Serotonin • Hydroxyindoleacetic Acid • Aspartic Acid • Enkephalin, Methionine • beta-Endorphin
作成者	濱田潤一，永田栄一郎

7) Goadsby PJ. The pharmacology of headache. Prog Neurobiol. 2000 Dec;62(5):509-25.
論文抄録	T Headache is a common problem which besets most of us at some time or the other. The pharmacology of headache is complex in an overall sense but can be understood in terms of the anatomy and physiology of the pain-producing structures. Migraine can be used as a template to understand the activation of nociceptive systems in the head and thus their neurotransmitter mediation and modulation. In recent years, the role of serotonin (5-HT) in headache pharmacology has been unravelled in the context of both understanding its role in the nociceptive systems related to headache and by exploiting its 5-HT1 receptor subtypes in headache therapeutics. The pharmacology of the head pain systems, as they are known and as they might evolve, are explored in the context of both, the anatomy and physiology of trigeminovascular nociception and in the context of clinical questions, such as those of efficacy, headache recurrence and adverse events.
文献 PubMed−ID	PMID: 10869781
文献タイトル (日本語)	頭痛の薬理学．
研究施設	Institute of Neurology , The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG , London , UK .
備考	Publication Types: • Review • Review, Academic MeSH Terms: • Brain Chemistry/drug effects • Headache/drug therapy* • Human • Serotonin Agents/therapeutic use* • Support, Non-U.S. Gov't Substances: • Serotonin Agents
作成者	濱田潤一，永田栄一郎