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脳底型片頭痛および片麻痺性片頭痛におけるトリプタン使用の是非

 

1) Klapper J, Mathew N, Nett R. Triptans in the treatment of basilar
　 migraine and migraine with prolonged aura. Headache. 2001 Nov-
　 Dec;41(10):981-4.
論文抄録
OBJECTIVE: To report on the use of triptans in migraine with prominent neurologic symptoms. BACKGROUND: As stated in their package inserts, the triptans are contraindicated in patients with basilar or familial hemiplegic migraine, and physicians are reluctant to prescribe these drugs to other patients with prominent or prolonged aura. METHODS: We evaluated 13 patients with basilar migraine, familial hemiplegic migraine, or migraine with prominent or prolonged aura who had received triptans. RESULTS: Excellent; no adverse events. CONCLUSION: The contraindication of triptans in basilar migraine should be reconsidered. Similarly, prominent or prolonged aura may not represent a reasonable contraindication to triptan therapy .
文献 PubMed−ID

PMID: 11903526

エビデンスレベル

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文献タイトル (日本語)

脳底型片頭痛と前兆遷延型片頭痛患者におけるトリプタン治療

目的
脳底型片頭痛 5 例，片麻痺型片頭痛 6 例と前兆遷延型片頭痛患者２例でのトリプタンの効果を検討
研究デザイン
症例研究
研究施設
Colorado Neurology and Headache Center, Denver, CO 80218, USA .
研究期間
不明
対象患者
13 人の脳底型片頭痛，家族性片麻痺性片頭痛と前兆遷延型片頭痛患者．
介入
それぞれの患者にトリプタンを内服させ経過観察．
主要評価項目とそれに用いた
統計学的手法
頭痛および随伴する神経症状の変化．
結果

すべての症例でトリプタンは頭痛および随伴症状を改善させた．副作用を認めず．

結論
トリプタンの脳底型片頭痛への禁忌を再考慮．また前兆遷延型片頭痛も禁忌ではないかもしれない．
備考

Publication Types:
•  Case Reports


MeSH Terms:
•  Adolescent
•  Adult
•  Classic Migraine/drug therapy*
•  Classic Migraine/genetics
•  Family Health
•  Female
•  Human
•  Male
•  Middle Aged
•  Migraine/drug therapy*
•  Migraine/genetics
•  Pedigree
•  Serotonin Agonists/contraindications
•  Serotonin Agonists/pharmacology
•  Serotonin Agonists/therapeutic use*
•  Sumatriptan/therapeutic use*
•  Triazoles/therapeutic use*


Substances:
•  Oxazolidinones
•  Serotonin Agonists
•  Triazoles
•  Sumatriptan
•  zolmitriptan
・rizatriptan

作成者
濱田潤一， 清水利彦